3,5-Dimethylphenylboronic acid, CAS 172975-69-8, is an aromatic boronic acid used mainly as a building block in palladium-catalyzed cross-coupling chemistry. Its two methyl groups are positioned at the 3- and 5-positions of the phenyl ring, while the boronic acid group provides the reactive handle for forming carbon–carbon bonds. At Maison Chemical, I help B2B buyers evaluate this intermediate by identity, application fit, documentation, packaging, and supply requirements rather than by name alone.
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The compound is commonly considered for pharmaceutical research, agrochemical development, medicinal chemistry, and other organic synthesis programs. Its molecular formula is generally represented as C8H11BO2, with a calculated molecular weight of approximately 149.98 g/mol. Because commercial form, purity, water content, analytical method, and packaging can vary by supplier, I recommend confirming the current specification before purchase.
3,5-Dimethylphenylboronic acid is an organoboron compound containing a substituted aromatic ring and a boronic acid functional group. The boron atom is bonded to the aryl group and hydroxyl groups, allowing the material to participate in reactions that transfer the aryl fragment to another organic partner. Its CAS number, 172975-69-8, is the primary registry identifier buyers should use when requesting quotations or technical documents.
The compound should not be confused with unsubstituted phenylboronic acid or other dimethylphenylboronic acid isomers. The positions of the methyl substituents influence molecular structure, reaction behavior, analytical identification, and suitability for a target synthesis. For this reason, I advise buyers to specify both the CAS number and the requested chemical name on purchase orders and technical inquiries.
The key functional feature is the aryl boronic acid group. In a Suzuki–Miyaura coupling, an arylboronic acid can react with an aryl or vinyl halide under suitable catalytic and basic conditions to form a new carbon–carbon bond. The boronic acid component is often selected because it is practical to handle and can be used to introduce a substituted aromatic group into a more complex molecule.
The 3,5-dimethyl substitution pattern adds hydrophobic methyl groups to the aromatic ring. These substituents can alter steric and electronic characteristics compared with phenylboronic acid, which may affect reaction optimization and the properties of the final product. Actual performance depends on the catalyst, solvent, base, substrate, temperature, concentration, and purification process, so I do not treat the compound as a universal drop-in reagent for every coupling system.
Commercial 3,5-dimethylphenylboronic acid is typically supplied as a solid research or production intermediate, but the exact appearance, particle size, and physical form should be confirmed from the supplier’s current certificate of analysis. Boronic acids may be sensitive to moisture and may undergo speciation or conversion to related boron-containing forms under certain conditions. Storage instructions should therefore follow the supplier’s safety data sheet and product-specific recommendations.
| Item | Information |
|---|---|
| Product name | 3,5-Dimethylphenylboronic acid |
| CAS number | 172975-69-8 |
| Molecular formula | C8H11BO2 |
| Approximate molecular weight | 149.98 g/mol |
| Chemical class | Aryl boronic acid and organic boronic acid intermediate |
One important use is the preparation of substituted biaryl structures during pharmaceutical discovery and process development. Medicinal chemists can use this intermediate to introduce a 3,5-dimethylphenyl group into a target scaffold, followed by additional functionalization or biological evaluation. Its value is greatest when the desired molecule specifically requires this substitution pattern and when the planned coupling route has been experimentally or technically assessed.
The compound may also be evaluated in the synthesis of crop-protection research compounds, specialty intermediates, and advanced materials-related molecules. In these applications, buyers usually need consistent identity and impurity control across multiple batches. A supplier should be able to discuss the available analytical package, lot traceability, packaging options, and whether the material is intended for laboratory, pilot, or larger-scale use.
For early-stage research, the material can support parallel synthesis and structure–activity relationship studies. For scale-up, the key issue changes from simple availability to reproducible reaction performance, stable supply, and a specification that can be transferred into internal quality systems. I recommend treating development-scale and production-scale purchasing as related but separate decisions.
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Buyers may encounter different commercial options based on quantity, purity, packaging, and intended use. A research-grade product may be appropriate for screening or route exploration, while a process-development project may require tighter control of assay, water, residual solvents, metals, and related organic impurities. These categories are not universal legal grades, so the buyer should rely on the supplier’s documented specification instead of an informal grade label.
Some boronic acids are supplied in forms that may differ in moisture content or solid-state characteristics. If the reaction is sensitive to water or if accurate molar charging is important, the specification should state how assay and water are measured. I also suggest confirming whether the quoted material is supplied under the exact CAS identity requested and whether any stabilizer, processing aid, or special handling condition applies.
A reliable procurement review should begin with identity and assay, but it should not end there. I normally encourage buyers to request the current certificate of analysis, analytical method summary where available, safety data sheet, packaging details, and a representative lot number. If the material will enter a regulated or tightly controlled process, the documentation requirements should be agreed before the purchase order is issued.
The lowest quoted price is not always the lowest total procurement cost. A more useful comparison includes product conformity, documentation, packaging, minimum order quantity, lead time, export experience, and the supplier’s ability to communicate about deviations. For a material used in a multistep synthesis, a small difference in purity or moisture may create additional development work, so the commercial decision should consider technical risk as well as unit price.
I recommend asking whether the supplier can provide a recent batch-specific COA, whether samples are available, and which analytical techniques are used for identity and purity testing. Buyers should also confirm available pack sizes, production or replenishment lead time, shipping conditions, and the process for handling nonconforming material. If a project may scale, ask whether the quoted source can support repeat orders under the same or an agreed revised specification.
For international procurement, confirm export documents, customs classification support where applicable, labeling language, and packaging compliance before dispatch. No supplier should promise identical performance across all reaction systems without supporting data, so a technically responsible quotation will distinguish confirmed product information from application guidance that still requires customer validation.
At Maison Chemical, I support B2B inquiries for 3,5-dimethylphenylboronic acid by organizing the discussion around product identity, intended use, quantity, destination, and documentation needs. We can review whether the requested specification is suitable for research, process development, or recurring supply evaluation. Where the application details are available, they help us provide a more relevant commercial response instead of a generic quotation.
For an initial inquiry, please state the required quantity, target purity or internal specification, packaging preference, delivery country, and desired timeline. If you need a sample before a larger order, identify the screening purpose and the analytical documents required for approval. Final availability, price, MOQ, and lead time should be confirmed against the current production and inventory situation.
3,5-Dimethylphenylboronic acid CAS 172975-69-8 is a useful procurement candidate when your synthesis requires a 3,5-dimethyl-substituted aryl fragment and a boronic acid coupling handle. Its identity and approximate molecular weight are well defined, but commercial suitability depends on the agreed specification, analytical evidence, and supply conditions. I recommend beginning with a documented sample or representative batch when the material is being introduced into a new route.
The next step is to send Maison Chemical your required quantity, purity target, application stage, destination, and documentation requirements. We can then help clarify the appropriate product specification, packaging, and quotation basis for your project. This approach gives procurement, quality, and technical teams a clearer basis for approving 3,5-dimethylphenylboronic acid for ongoing B2B supply.
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