4-tert-Buthoxyphenyl boronic acid CAS 176672-49-4 is an aryl boronic acid used primarily as a building block in palladium-catalyzed cross-coupling chemistry, especially Suzuki–Miyaura reactions. It combines a boronic acid functional group with a para-tert-butoxy-substituted phenyl ring, allowing chemists to introduce a protected phenoxy-related structure into more complex molecules. At Maison Chemical, I recommend evaluating this material through confirmed identity, assay, impurity profile, packaging, and project-specific supply requirements rather than relying on the product name alone.
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This guide explains where the compound is used, which specifications buyers should request, how to compare supplier offers, and what information should be confirmed before placing an order. Because specifications can vary by manufacturing route and grade, the final acceptance criteria should always be based on the supplier’s current certificate of analysis and the buyer’s internal requirements.
This guide is intended for procurement teams, medicinal chemistry groups, process chemists, contract research organizations, and distributors sourcing organic boronic acids. It is also relevant to laboratories that need a consistent aryl building block for parallel synthesis or route-screening programs. The information is designed for purchasing and supplier evaluation, not as a substitute for a validated synthetic procedure or a formal safety assessment.
4-tert-Buthoxyphenyl boronic acid is an organoboron compound containing an aryl boronic acid group and a tert-butoxy substituent in the para position of the aromatic ring. The boronic acid group is the key reactive site in many carbon–carbon bond-forming reactions. Its molecular structure can therefore be used to transfer a substituted phenyl group into a target molecule under suitable reaction conditions.
The compound is commonly supplied as a research or synthesis intermediate. Its practical value depends on more than the name or CAS number: the physical form, purity, water content, stability, and impurity pattern may influence reaction performance. For this reason, I advise buyers to request a current specification sheet and batch-specific COA before approving material for a critical project.
The most relevant application is Suzuki–Miyaura coupling with an aryl or vinyl halide, triflate, or a related electrophilic partner. In the presence of a suitable palladium catalyst, base, solvent system, and reaction conditions, the boronic acid can participate in carbon–carbon bond formation. The exact conversion and selectivity depend on the substrates and process conditions, so a supplier should not promise universal reaction performance without application-specific evidence.
Medicinal chemistry teams may use this building block to prepare small libraries containing a para-substituted biaryl or related aromatic motif. Its use can support structure–activity relationship studies when researchers want to vary the second coupling partner while retaining the tert-butoxyphenyl fragment. In these applications, small pack sizes, dependable analytical data, and rapid sample availability can be as important as the nominal assay.
Process chemists may evaluate the material during route scouting, scale-up, or preparation of advanced intermediates. At this stage, control of trace impurities, residual metals, water, and lot-to-lot consistency becomes more important. A material suitable for early discovery may require additional qualification before it is used in a regulated or tightly controlled manufacturing process.
There is no single universal specification that fits every application. A practical buyer specification normally combines identity tests, purity requirements, physical description, and impurity controls. The following table shows the categories I recommend discussing with a supplier.
| Specification Area | What to Confirm | Why It Matters |
|---|---|---|
| Identity | CAS number, name, structure, and analytical confirmation | Prevents substitution or confusion with a positional isomer |
| Assay and purity | HPLC, GC, NMR, or another agreed method; reported in % where applicable | Supports reaction planning and impurity assessment |
| Water content | Karl Fischer or another validated method, reported in % or ppm | Boronic acids may be sensitive to moisture and form-related variation |
| Residual solvents | Solvent identity and quantitative limits | Important for process development and downstream purification |
| Physical form | Appearance, color, particle form, and net weight | Helps with handling, weighing, and batch acceptance |
| Packaging | Container type, closure, labeling, and storage instructions | Supports product integrity during transport and storage |
For reference, the commonly cited molecular formula is C10H15BO3, and the calculated molecular weight is approximately 194.04 g/mol. These values should be checked against the exact commercial form, because hydration, solvates, analytical conventions, or documentation errors can affect how a product is represented. I recommend treating the COA, SDS, and specification sheet as the controlling documents for procurement.
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Start by matching the requested CAS 176672-49-4 with the chemical name, structure, and intended use. Ask whether the quoted material is the anhydrous compound or another form, and request representative analytical data. If the project depends on a specific positional isomer, identity confirmation should be part of the incoming quality process.
Research-scale screening may require a reliable standard grade with clear assay information, while process development may require tighter controls for metals, solvents, and water. Do not select solely on the highest advertised purity if the method, test conditions, and impurity profile are not disclosed. The best specification is the one that matches the reaction and downstream quality requirements.
Compare MOQ, sample availability, standard pack sizes, production lead time, and shipping conditions. A low unit price may not be advantageous if the MOQ is excessive or if the supplier cannot support repeat batches. Buyers should request a written quotation that separates product price, packaging, documentation, and delivery assumptions.
For an ongoing synthesis program, ask how the supplier manages batch records, retained samples, change notification, and repeat-order consistency. Maison Chemical supports B2B sourcing discussions by clarifying product requirements, documentation expectations, packaging needs, and delivery planning. Availability should be confirmed at the time of inquiry rather than assumed from a catalogue listing.
The price of 4-tert-Buthoxyphenyl boronic acid can vary according to order quantity, assay target, packaging, production route, analytical requirements, and shipping destination. Small quantities often carry higher unit costs because analytical handling and packaging represent a larger share of the order. Larger quantities may improve the unit economics, but they should be balanced against storage conditions, shelf-life information, and forecast certainty.
Lead time also depends on whether the requested quantity is available from stock or requires production. For planning purposes, buyers should state the required quantity, target delivery date, destination country, documentation needs, and whether a pre-shipment sample is required. This information allows the supplier to provide a more realistic quotation instead of an unqualified estimate.
When contacting Maison Chemical, provide the CAS number, target quantity, preferred package size, application stage, required assay, destination, and requested delivery window. If your organization has an established incoming specification, sharing it at the quotation stage can reduce clarification cycles. You may also request available documentation such as a COA, SDS, product specification, and packaging information, subject to the product and order requirements.
For repeat purchasing, I recommend agreeing in advance on critical quality attributes and acceptable documentation. These may include identity, assay method, water limit, residual solvent controls, appearance, packaging configuration, and change-notification expectations. Clear requirements help align the buyer, manufacturer, and logistics provider before commercial production begins.
4-tert-Buthoxyphenyl boronic acid CAS 176672-49-4 is a practical aryl boronic acid building block for cross-coupling research, medicinal chemistry, and selected process-development applications. Its suitability depends on the target reaction, required impurity controls, material form, and supply conditions. The most reliable buying decision combines confirmed identity, appropriate analytical specifications, documented batch quality, and realistic commercial terms.
Your next step should be to define the required quantity, assay, documentation, packaging, and delivery schedule, then request a current quotation and COA from Maison Chemical. Our team can review the requirement and discuss product availability, specification alignment, and B2B supply planning. Contact Maison Chemical with your project details so we can help determine the most suitable supply option for 4-tert-Buthoxyphenyl boronic acid.
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