Antibodies are specialized proteins produced by the immune system to identify and attack foreign invaders, such as bacteria, viruses and toxins. They are Y-shaped molecules which contain four polypeptide chains: two identical “heavy” chains and two identical “light” chains.
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In contrast to humans, some species of animals, including camels, llamas, alpacas and sharks, can make antibodies that contain only "heavy” chains. This exposes the antigen binding part of the antibody, which scientists are able to isolate and create a small protein fragment known as a NANOBODY molecule.1,2
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NANOBODY technology is helping our scientists explore new therapeutic approaches that could one day replace complex treatment regimens with single, multi-action medicines. This could minimize the side effects of taking multiple treatments, and potentially improve administration; NANOBODY molecules can also be administered orally, which may offer a more convenient and less invasive option for many people.
For these reasons, NANOBODY molecules have become an essential tool in drug discovery. Combined with Sanofi's large-scale manufacturing capacity, NANOBODY molecules and other cutting-edge technologies are empowering our teams to develop the medicines of tomorrow.
Want more information on Nanobody (VHH) Discovery Platform? Feel free to contact us.