2-Fluoro-6-methoxyphenylboronic acid (CAS 78495-63-3) is an arylboronic acid used as an organoboron coupling partner in Suzuki–Miyaura chemistry. It can introduce a 2-fluoro-6-methoxyphenyl group when coupled with a suitable aryl or vinyl halide or related electrophile under compatible reaction conditions. Buyers should confirm identity, assay, documentation, packaging, and delivery timing before ordering, because availability and commercial specifications can vary by supplier and lot. This guide outlines the checks I recommend before requesting a quotation from Maison Chemical or another supplier.
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This guide is intended for procurement teams, process chemists, medicinal chemistry groups, and chemical distributors evaluating this building block for research, development, or production planning. It is useful when you need to compare supplier offers or determine what information to include in a request for quotation. It is not a substitute for reaction development, a product-specific safety review, or a supplier’s current technical documentation. Buyers should base final decisions on their intended application and the documents supplied for the specific lot.
In a Suzuki–Miyaura reaction, an organoboron reagent couples with a suitable organic electrophile, commonly an aryl halide, using a palladium catalyst and a base. This boronic acid serves as the source of the substituted aryl group; the selected electrophile and reaction conditions determine the resulting product and its practical yield. Its fluoro and methoxy substituents are part of the structure transferred into the coupled product. Their presence alone does not guarantee a particular conversion, selectivity, or reaction time.
For procurement calculations, the listed molecular weight of approximately 169.95 g/mol provides a useful starting point. At that molecular weight, 1 mmol corresponds to approximately 169.95 mg of material before any adjustment for assay or handling losses. For accurate weighing and stoichiometry, use the lot’s reported assay where available and confirm whether the stated value is on an as-is or corrected basis.
Do not assume that two listings with the same name offer identical commercial specifications. Before purchasing, ask the supplier to confirm the product name, CAS number, molecular formula, molecular weight, available grade, assay method, and lot-specific assay. Depending on your application, you may also need information on appearance, water content, residual solvents, or other impurity limits; request these only where they are relevant to your process or quality system.
| Information to check | Why it matters |
|---|---|
| CAS number and chemical identity | Helps distinguish the requested material from similarly named compounds or positional isomers. |
| Assay and test method | Supports charge calculations and helps determine whether the grade suits the intended use. |
| Lot documentation | Lets your technical or quality team review the actual lot rather than relying on a general listing. |
| Packaging and storage guidance | Helps assess handling, receipt, and storage needs at your site. |
Start with the purpose of the purchase: exploratory screening, route development, scale-up, or routine production. A small research requirement may prioritize prompt availability and convenient pack size, while a development program may place more weight on batch consistency, traceable documentation, and the ability to discuss repeat supply. Production buyers should also consider how much material is needed for planned campaigns and whether the supplier can support future demand. These priorities should be stated clearly during the quotation process.
Reaction suitability must be evaluated in the context of the full coupling pair. The electrophile, catalyst, base, solvent, water content, temperature, and reaction time can all influence the outcome, and conditions successful for one substrate may not transfer directly to another. Boronic acids can also be affected by competing pathways under some reaction conditions, so monitor conversion and product profile during development. Treat literature or internal conditions as starting points to validate, not as a product-specific performance guarantee.
Specify the quality attributes that are essential to your work instead of requesting a vague “high-purity” grade. For example, tell the supplier whether you require a defined assay threshold, a particular analytical method, or additional impurity information. If your project has internal acceptance criteria, share them before ordering so the supplier can confirm whether the offered material and available documentation meet your needs. Do not interpret a catalogue value as a lot-specific result unless the supplier identifies it as such.
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Ask which documents will accompany the shipment or can be provided for review, such as a certificate of analysis and safety data sheet. Confirm that the documents correspond to the offered product and, when applicable, the supplied lot. If your organization has vendor qualification or change-control requirements, discuss them early rather than waiting until material is needed. Maison Chemical can be contacted to clarify the current product documentation available for the requested item.
Request pricing against the quantity and pack size you actually need, and confirm whether the quote is for a specific grade or specification. Minimum order quantity, lead time, stock status, and shipment arrangements are supplier- and order-dependent, so I recommend obtaining current confirmation rather than relying on general assumptions. Ask whether the quoted timing refers to dispatch or expected delivery, and clarify any packaging or transport constraints relevant to your destination. Record these terms alongside technical specifications when comparing offers.
There is no dependable universal price or lead time that applies to every order of CAS 78495-63-3. The quote may depend on requested quantity, grade, packaging, current availability, and destination, while MOQ can vary by supplier and stock configuration. For a useful comparison, request a written quotation that states the quantity basis, currency, quote validity, MOQ, estimated dispatch timing, and shipping terms. If you expect repeat orders, ask whether supply planning or forecast-based discussions are available.
When assessing Maison Chemical or another prospective supplier, focus on verifiable information and clear communication. A practical evaluation includes identity confirmation, specification fit, lot-document availability, commercial terms, and the supplier’s ability to respond to technical or logistics questions. Avoid making a decision based only on a low unit price if the grade, documentation, or delivery assumptions are unclear. Use the checklist below to prepare an efficient inquiry.
One frequent mistake is relying on the chemical name alone and overlooking CAS identity or positional-isomer distinctions. Another is comparing prices without checking whether assay, packaging, and documentation are equivalent. Buyers may also order a production quantity before confirming that the material performs acceptably with their specific electrophile and conditions. Where practical, align initial procurement with the project’s experimental plan and define acceptance criteria before committing to larger volumes.
Storage and handling decisions should follow the supplier’s current safety data sheet and product-specific guidance. Do not assume a storage temperature, shelf life, or special handling requirement without documentation for the material being supplied. On receipt, review container condition and lot paperwork according to your organization’s procedures. If a discrepancy appears, raise it with the supplier before using the material.
2-Fluoro-6-methoxyphenylboronic acid, CAS 78495-63-3, is a defined arylboronic acid coupling partner for Suzuki–Miyaura applications, but purchasing suitability depends on the required grade, lot evidence, reaction context, and commercial terms. Confirm the identity and specifications first, then assess the offered documentation, quantity, MOQ, lead time, and shipment details against your project needs. For process decisions, validate the reagent with your intended coupling partner and reaction conditions rather than relying on generalized expectations. To request current availability and a quotation from Maison Chemical, provide your target quantity, required specification, destination, and any documentation requirements.
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