If you are sourcing 1-Methyl-4-pyrazole boronic acid pinacol ester, CAS 761446-44-0, you should evaluate more than the chemical name and quoted price. I recommend confirming the identity, molecular specifications, lot documentation, packaging, export requirements, and supply continuity before placing an order. This compound is commonly considered a heteroaryl boronic ester building block for medicinal chemistry, pharmaceutical intermediate development, and Suzuki–Miyaura coupling research. At Maison Chemical, I help buyers assess the right specification and request a practical quotation based on quantity, destination, and documentation requirements.
This guide is intended for procurement teams, process chemists, medicinal chemistry groups, contract research organizations, pharmaceutical intermediate manufacturers, and distributors. It is useful when you are purchasing a laboratory quantity, screening several suppliers, or preparing a repeat-order plan. I also recommend it to buyers who need a structured checklist before requesting a quotation for international delivery.
The product may be sold under slightly different naming conventions, so a search based only on a shortened name can create confusion. I advise buyers to provide the CAS number, chemical name, required quantity, target specification, destination country, and documentation expectations in the first inquiry. This gives the supplier enough information to confirm whether the requested material and commercial terms match your project.
1-Methyl-4-pyrazole boronic acid pinacol ester is a boronic ester derivative containing a methyl-substituted pyrazole ring and a pinacol-protected boron group. The boronic ester functionality is commonly used as a coupling handle in synthetic chemistry, particularly where a heteroaryl fragment must be introduced into a larger molecule. Its exact suitability depends on the reaction system, substrate, catalyst, base, solvent, temperature, and work-up conditions.
The commonly associated formula is C11H17BN2O2, and the approximate molecular weight is 220.08 g/mol. These are useful identity checks, but they should not replace lot-specific analytical confirmation. For purchasing and inventory control, I suggest recording the CAS number, systematic name, molecular formula, molecular weight, internal material code, and supplier batch number together.
The first review should confirm that the supplied material matches CAS 761446-44-0 and the intended chemical structure. Buyers commonly request the product name, CAS number, molecular formula, molecular weight, appearance, and storage recommendation in the technical data sheet or certificate of analysis. Appearance alone is not sufficient for release, because color and physical form can vary with handling, packaging, and storage conditions.
| Specification Area | What I Recommend Confirming | Why It Matters |
|---|---|---|
| Identity | CAS 761446-44-0, chemical name, structure, and analytical identity | Prevents confusion with related pyrazole or boronic ester compounds |
| Composition | Formula C11H17BN2O2 and approximate molecular weight 220.08 g/mol | Supports purchasing, calculations, and material registration |
| Purity | Assay or chromatographic purity with a defined test method | Allows comparison between suppliers on a consistent basis |
| Impurities | Water, residual solvents, related substances, or other agreed parameters | May affect reaction performance and downstream purification |
| Documentation | Lot-specific COA, SDS, TDS, and shipping information where applicable | Supports quality review, handling, and traceability |
A certificate of analysis should be linked to the actual production lot rather than provided as a generic document. Depending on your quality system, you may request chromatographic data, identity data, water content, residual solvent information, or additional tests. I recommend agreeing on the required test items before production or dispatch, because adding a new analytical requirement after shipment can delay material approval.
The safety data sheet is also important for handling, storage, transport classification, and emergency response. A technical data sheet can provide useful information about standard packaging, storage conditions, and recommended shelf-life management, but buyers should distinguish general product information from lot-specific test results. If your organization requires a particular format, such as a signed COA or supplier questionnaire, include that requirement in the initial request.
This compound may be considered for synthetic routes that use a heteroaryl boronic ester as a coupling partner. In medicinal chemistry, it can support the preparation of analogues containing a methyl-pyrazole fragment, while process development teams may evaluate it as an intermediate in a longer synthesis. These applications are route-dependent, so I do not recommend assuming that one supplier’s nominal purity will deliver identical results in every reaction.
For early-stage screening, a standard research or synthetic-grade specification may be sufficient if your internal procedure includes purification and analytical checks. For route development or commercial intermediate production, you may need tighter controls on related substances, water, residual solvents, particle handling, and batch-to-batch consistency. The correct specification should therefore be based on the material’s role in your process, not only on the lowest available price.
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Start by documenting the required quantity, intended use, target purity, preferred packaging, delivery location, and required documents. For example, a development laboratory may request a small research pack, while a manufacturing buyer may need multiple batches with retained samples and a formal quality review. Stating the intended application helps the supplier recommend a suitable commercial grade without making unsupported assumptions.
Do not compare a supplier quoting “high purity” with another supplier quoting a numerical assay unless both descriptions are clarified. Ask for the analytical method, reporting basis, test date, and whether the stated value is a release specification or a typical result. I also recommend checking whether the COA includes the batch number, manufacturing date, retest or expiry information, and authorized approval.
Boronic ester materials should be packaged in a way that protects them from moisture, contamination, and unnecessary exposure during handling. The exact packaging should be matched to quantity, shipping duration, and your laboratory or production environment. Before ordering, confirm the recommended storage temperature, container type, secondary packaging, labeling, and whether special transport instructions apply.
Price, MOQ, and lead time are normally quotation-based because they depend on quantity, stock status, production scheduling, packaging, and destination. A low unit price may not represent the lowest total cost if the supplier cannot provide the required documents or if the delivery schedule does not fit your project. For repeat supply, ask whether the quoted material is from available stock or requires a new production batch.
One common mistake is relying on the product name without confirming the CAS number and structure. Another is requesting a price without specifying the quantity, destination, or documentation package, which can lead to incomplete comparisons. Buyers should also avoid treating a catalog listing as proof of current availability, since stock status and production timing can change.
A further risk is approving a supplier based only on a single sample. For an important synthetic route, I suggest reviewing the supplier’s ability to provide traceable lots, consistent packaging, responsive technical communication, and a documented process for handling deviations. These factors can be as important as the initial analytical result when the material will be ordered repeatedly.
At Maison Chemical, I approach this product as a B2B sourcing requirement rather than a simple catalog transaction. I can help organize a quotation around CAS 761446-44-0, required quantity, target specification, packaging, delivery destination, and document needs. Where applicable, the document package can be discussed in advance so that buyers know what information will be available for technical and purchasing review.
We also recognize that different customers require different levels of support. A research buyer may prioritize fast confirmation and practical packaging, while a pharmaceutical intermediate manufacturer may focus on lot traceability, specification alignment, and repeat-supply planning. I recommend sharing your internal acceptance criteria early, allowing the quotation and document review to reflect the actual project requirements.
The best way to buy 1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0 is to evaluate identity, analytical specifications, documents, packaging, commercial terms, and supplier reliability together. The approximate formula C11H17BN2O2 and molecular weight of 220.08 g/mol provide useful starting checks, but a lot-specific COA remains essential for purchasing decisions. I recommend defining your technical and delivery requirements before comparing quotations.
If you are planning a laboratory purchase, process-development project, or repeat supply program, contact Maison Chemical with your required quantity, specification, destination, and document expectations. We can then review the appropriate supply option and prepare a quotation for your evaluation. This structured approach helps reduce avoidable sourcing delays while keeping the purchase aligned with your chemistry and quality requirements.
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